Laurent Pierot

Prof Dr Laurent Pierot

President, Editor-in-Chief for EJMINT

Service de Radiologie, Hôpital Maison Blanche, 45, rue Cognacq-Jay, 51100 REIMS


Tel: 03 26 78 75 66

Secr: 03 26 78 75 68

Fax: 03 26 78 35 31

Email: lpierot@gmail.com

 

Medical School: Faculty of Medicine Saint-Antoine (Paris)

Residency and Fellowship: Neurology and Radiology

Medical Doctor: 1990

Graduated in Radiology: 1990

1990-1993: Assistant, Department of Neuroradiology (Professor J. Chiras), La Salpetriere Hospital, Paris

1993-1995: Assistant, Department of Interventional Neuroradiology (Professor J. Moret), Foundation Rothschild Hospital, Paris

1995-2001: Head of the Department of Diagnostic and Therapeutic Neuroradiology, Foch Hospital, Suresnes, Paris

2001-present: Professor of Radiology, Faculty of Medicine, Reims

2001-present: Head of the Department of Radiology, University Hospital, Reims

2007-2011: President of the French Society of Neuroradiology (SFNR)

Clinical Activities

Interventional Neuroradiology:

  • Endovascular treatment of ruptured and unruptured intracranial aneurysms using coils, stents, remodelling technique, flow diverters, occlusion of the parent vessel
  • Endovascular treatment of brain AVMs using glue and Onyx
  • Endovascular treatment of dural fistulas using arterial and venous approaches
  • Endovascular treatment of acute stroke (intraarterial chemical and mechanical thrombolysis)
  • Endovascular treatment of intracranial and cervical arterial stenosis
  • Embolization of intracranial and cervical tumors (meningiomas, chemodectomas,…)
  • Interventional spine

Diagnostic Neuroradiology

Research

Principal Investigator in multiple prospective, multicenter trials:

 

  • Matrix 2004: multicenter, prospective, French trial dealing with the safety and efficacy of Matrix coils in the treatment of intracranial aneurysms
  • ATENA: multicenter, prospective, French trial dealing with the endovascular treatment of unruptured intracranial aneurysms (27 French centers, 649 patients)
  • BRAVO: multicenter, prospective, European trial dealing with the use of Onyx in the endovascular treatment of brain AVMs
  • CLARITY: multicenter, prospective, French trial dealing with the endovascular treatment of ruptured aneurysms using GDC and Matrix coils (20 French centers, 833 patients)

Publications

Publications in International and French medical journals: 86 (French papers: 20; international papers: 66)

Oral presentations at international and French meetings: more than 200

Publication Fields:

  • Diagnostic and therapeutic neuroradiology
  • Imaging, classification and treatment of vascular malformations of the brain
  • Endovascular treatment of intracranial aneurysms, brain AVMs, dural fistulas
  • Imaging and endovascular treatment of spinal vascular malformations
  • MR imaging of cerebral and spinal diseases
  • Functional MR imaging

Editorial Activities

Journal of Neuroradiology: Associate Editor

Stroke: Section Editor (Interventional Radiology)

AJNR: Member of the Editorial Board

Neurosurgery: Reviewer
 

More Recent International Publications (in the past five years)

  1. Follow-up of intracranial aneurysms selectively treated with coils: prospective evaluation of contrast-enhanced MR Angiography
    L. Pierot, C. Delcourt , F. Bouquigny, D. Breidt, B. Feuillet, O. Lanoix, S. Gallas
    AJNR Am J Neuroradiol, 2006, 27 (4): 744-749.
  2. Preoperative embolization of a cervico-dorsal paraganglioma by direct percutaneous injection of ONYX® and endovascular delivery of particles
    R.S. Quadros, S. Gallas, C. Delcourt,  E. Dehoux, B. Scherperel, L. Pierot
    AJNR Am J Neuroradiol., 2006, 27:1907-1909.
  3. Endovascular Treatment of Intracranial Aneurysms with Matrix™ Detachable Coils : Immediate Post-treatment Results from a Prospective, Multi-Center Registry
    L. Pierot, A Bonafé, S. Bracard, X. Leclerc, and investigators
    AJNR Am J Neuroradiol, 2006, 27: 1693-1699.
  4. fMRI study of problem-solving after severe traumatic brain injury
    F. Cazalis, A. Feydy, R. Valabrègue, M. Pélégrini-Issac, L. Pierot, Ph. Azouvi.
    Brain Injury, 2006, 20: 1019-1028.
  5. Endovascular treatment of middle cerebral artery aneurysms as first option: a single center experience of 92 aneurysms
    R. Quadros, S. Gallas, R. Noudel, P. Rousseaux, L. Pierot
    AJNR Am J Neuroradiol, 2007, 28: 1567-1572.
  6. Endovascular Treatment of Intracranial Aneurysms with Matrix™ Detachable Coils : Midterm Anatomical Follow-up from a Prospective, Multi-Center Registry
    L. Pierot, X. Leclerc, A. Bonafé, S. Bracard, and Matrix Registry Investigators
    AJNR Am J Neuroradiol, 2008, 29: 57-61.
  7. Feasibility, Procedural Morbidity and Mortality, and Long-Term Follow-Up of Endovascular Treatment of 321 Unruptured Aneurysms.
    S. Gallas, J. Drouineau, J. Gabrillargues, A. Pasco, C. Cognard, L. Pierot, D. Herbreteau
    AJNR Am J Neuroradiol, 2008, 29: 63-68.
  8. Clinical outcome of patients harbouring unruptured intracranial aneurysms treated by endovascular approach: results of the ATENA trial.
    L. Pierot, L. Spelle, F. Vitry, for the ATENA investigators
    Stroke, 2008, 39: 2497-2504.
    First price of the Innovation Award (attributed by Stroke)
  9. Endovascular treatment of intracranial aneurysms using Matrix Coils : Short and Mid-term results.
    L. Pierot, X. Leclerc, A. Bonafé, S. Bracard, and Investigators
    Neurosurgery, 2008, 63: 850-857.
  10. Endovascular treatment of Unruptured Intracranial Aneurysms : Comparison of Safety of remodeling technique and standard treatment with coils.
    L. Pierot, L. Spelle, X. Leclerc, C. Cognard, A. Bonafé, J. Moret
    Radiology, 2009, 251: 846-855.
  11. Incidence of basioccipital hypoplasia malformation type I: comparative morphometric study of the posterior cranial fossa.
    R. Noudel, N. Jovenin, C. Eap, B. Scherpereel, L. Pierot, P. Rousseaux
    J Neurosurg, 2009, 111: 1046-1052.
  12. Immediate anatomical results after the endovascular treatment of unruptured intracranial aneurysms : analysis of the ATENA series.
    L. Pierot, L. Spelle, F. Vitry, for the ATENA investigators
    AJNR Am J Neuroradiol, 2010, 31: 140-144.
  13. Immediate anatomical results after endovascular treatment of ruptured intracranial aneurysms: analysis of the CLARITY series.
    L. Pierot, C. Cognard, F. Ricolfi, R. Anxionnat, for the CLARITY investigators
    AJNR Am J Neuroradiol, 2010, 31: 907-911.
  14. Similar safety in centers with low and high volumes of endovascular treatments of unruptured intracranial aneurysms: analysis in ATENA series.
    L. Pierot, L. Spelle, F. Vitry, for the ATENA investigators
    AJNR Am J Neuroradiol, 2010, 31: 1010-1014.
  15. Vasospasm after aneurysmal subarachnoid hemorrhage: Recent advances in endovascular management.
    L. Pierot, M. Aggour, J. Moret
    Current Opinion in Critical Care, 2010, 16: 110-116.
  16. Ruptured intracranial aneurysms: Factors affecting the rate and outcome of endovascular treatment complications in a series of 782 patients (CLARITY).
    L. Pierot, C. Cognard, R. Anxionnat, F. Ricolfi, and CLARITY investigators
    Radiology, 2010, 256: 916-923.
  17. Abciximab treatment modalities for thromboembolic events related to aneurysm coiling.
    M. Aggour, L. Pierot, K. Kadziolka, Ph. Gomis, J.-P. Graftieaux
    Neurosurgery, 2010, 67 : 503-508.
  18. Endovascular treatment of very small unruptured aneurysms: rate of procedural complications, clinical outcome, and anatomical results.
    L. Pierot, C. Barbe, L. Spelle, and ATENA investigators
    Stroke, 2010, 41: 2855-2859.
  19. The remodelling technique for endovascular treatment of ruptured intracranial aneurysms had a higher rate of adequate occlusion than did conventional coil embolization with comparable safety.
    L. Pierot, C. Cognard, R. Anxionnat, F. Ricolfi, and CLARITY investigators
    Radiology, 2011, 258: 546-553.
  20. Can flow divert stent devices prevent aneurismal rupture? Direct CCF following intracavernous carotid aneurysm treatment with Silk stent.
    W. Mustafa, K. Kadziolka, R. Noudel, L. Pierot
    Interventional Neuroradiology, 2010, 16: 4478-450.
  21. Letter by Pierot regarding article “Flow-diverter stent for the endovascular treatment of intracranial aneurysms: a prospective study in 29 patients with 34 aneurysms”
    L. Pierot
    Stroke, 2011, 42: e38-39.
  22. Safety and efficacy of balloon remodelling technique during endovascular treatment of intracranial aneurysms: Critical review of the literature
    L. Pierot, C. Cognard, L. Spelle, J. Moret
    AJNR Am J Neuroradiol (in press)
  23. Results of embolization used as the first treatment choice in a consecutive non selected population of ruptured aneurysms.  Clinical Results of the Clarity GDCTM study.
    C. Cognard, L. Pierot, R. Anxionnat, F. Ricolfi, and CLARITY investigators
    Neurosurgery (in press)
  24. Mid-term anatomical results after endovascular treatment of ruptured intracranial aneurysms with GDC™ and Matrix™ coils: analysis of the CLARITY series.
    L. Pierot, C. Cognard, F. Ricolfi, R. Anxionnat, on behalf of CLARITY group
    AJNR Am J Neuroradiol (in press)